Failed IVF Cycle: Factors Affecting Implantation
I know this is something every single one of you is concerned about... IMPLANTATION! Sadly, you are probably very well aware of the fact that just because you have an embryo put in, doesn’t mean you are going to get pregnant. But why? We are putting the embryo right in there!!! Why wouldn’t it work?⠀
Failed IVF Cycle: Factors Affecting Implantation
Sadly, the majority of embryos are not chromosomally normal. And the older you are, the less normal embryos you have. This would be one of the main reasons an embryo didn’t work, or miscarried early. ⠀
Uterine issues
Uterine issues such as fibroids, polyps, adhesions, endometritis (inflammation) can all interfere with implantation. You many also have a congenital malformation such as septate uterus or bicornuate uterus. Your doctor may suggest a test called hysteroscopy to check your uterus for abnormalities. ⠀
Endometrial issues
Endometrial Issues such as being too thin, or progesterone wasn’t supportive enough to maintain a thick lining. The endometrium needs to be receptive to an embryo!
Embryo issues
Embryo issues can include the metabolism of the embryo and how is genes are functioning, the trophectoderm wasn’t good enough to hatch and invade the endometrium. If you had a day 3 embryo, a lot of embryos will do great until day 3 and then fail to develop after then as the genome won’t activate, poor DNA
Immune issues
Immune issues these are relatively new in the area of reproductive medicine and are highly controversial among specialists. Some specialists claim that increased natural killer (NK) cells affect the immune system and it’s response to an embryo leading to issues with implantation or early miscarriage. There is currently not enough strong evidence to support this and the proposed treatments such as intralipids, IV immunoglobulins and steroids.
Medical Disclaimer:
The information provided in this blog is intended for general informational purposes only and should not be considered as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your healthcare provider or qualified medical professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this blog.
