What to Know About an Unexplained Infertility Diagnosis
Ask an Expert addresses reader questions. Today we share part two of our expert series with Dr. Bruce Lessey of Wake Forest, who will answer some questions related to unexplained infertility. Dr. Lessey is an internationally recognized leader in uterine receptivity research and the identification of markers associated with unexplained infertility.
This article is sponsored by ReceptivaDx
Are there any blood tests to take for unexplained infertility?
Almost all IVF centers will test for a hormone called FSH (Follicle stimulating Hormone). Results of this test provide insight into the egg quality, quantity and reproductive potential. Other hormone tests include (LH) Luteinizing hormone and Estradiol, both of which provide insight into your ovarian reserve. Other screening tests include past exposure to rubella, varicella (Chicken pox), Hepatitis B and C, HIV, and Syphilis. There are also genetic tests offered which can provide additional insight. While blood tests are very useful, they only provide one piece of the puzzle in uncovering the cause of unexplained infertility,
Diet to follow for unexplained infertility?
There is a lot in the literature about diet and fertility. Most of the studies are not rigorous enough to scientifically make conclusions specific to unexplained infertility. However, it logically makes sense that eating a diet that reduces inflammation by minimizing sugar, processed carbs, trans fats, and red meat while increasing plant-based options including whole grains, fruits and vegetables is a foundation for a successful pregnancy
Could environmental factors be responsible for unexplained infertility?
Many of the environmental hazards are related to aero hydrocarbons. And aero hydrocarbon receptors are tied in completely with his whole pathway. Inflammation can come from environmental toxins, and this is something we would like to put a grant in and study further. It’s an area of great concern given the way the environment is headed.
What are my chances of conceiving naturally with this diagnosis?
The published clinical studies in an IVF setting tell us that women presenting with unexplained infertility and are positive for BCL6 (suggesting endometriosis as cause), have an 11% chance of a live birth on their next transfer. Compare this to women presenting with unexplained infertility who test negative (suggesting no endometriosis). Their probability of a live birth on the next transfer is about 60%, consistent with current success rates of IVF centers across the country.
What is the procedure for the ReceptivaDx test?
The ReceptivaDx test uses a simple endometrial biopsy (can be done in OB office) taking a small sample of endometrial tissue and testing it for a protein marker called BCL6, highly associated with endometriosis. The sample is sent to a lab and analyzed within 3-6 days. Depending on results, the patient can then be treated surgically or with hormones and then reattempt IVF or naturally
Can you explain markers of uterine receptivity?
Markers of uterine receptivity is just a fancy way of describing protein markers associated with problems of the uterine lining, it doesn’t matter if you have perfect eggs and perfect timing, If the uterine lining is not receptive to a fertilized egg, it will not stay there for the duration of the pregnancy, Inflammatory conditions such as endometriosis are disruptive to the uterine lining,
Tests like ReceptiviaDx can predict the likelihood of having these inflammatory conditions, even if asymptomatic, allowing the woman to be treated and resolving the condition long enough to have a baby.
ReceptivaDxTM is a first of its kind test for the detection of inflammation of the uterine lining most commonly associated with endometriosis, a leading cause of infertility and implantation failure. Women testing positive for ReceptivaDx are 5 times less likely to succeed in IVF than women testing negative. ReceptivaDxTM (BCL6 Test) Predicts Chances for a Successful Transfer and Successful Pregnancy. 75% of women with unexplained infertility will test positive for BCL6
Dr. Bruce Lessey of Wake Forest University. Dr. Lessey is an internationally recognized leader in uterine receptivity research and the identification of markers associated with unexplained infertility. He is the founder of the research on BCL6, the test you can order as ReceptivaDx through our website. He has served on multiple editorial boards for major journals and published over 150 peer reviewed articles, with a focus on infertility, endometriosis and the role of the endometrium in embryo implantation. Just as important, Dr. Lessey still sees patients regularly at his Wake Forest location. He has more than 30 years' experience in IVF.
Medical Disclaimer:
The information provided in this blog is intended for general informational purposes only and should not be considered as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your healthcare provider or qualified medical professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this blog.
